English spoken ACTINMUN Technical Area (+52)2441105694 and (+52)2212590373.

IMPORTANT DATA: ACTINMUN SHIPPING AREA: (+52) 2441149836 and (52)2444460015, English spoken Technical Area (+52)2441105694, (+52)2212590373 We can send the ACTINMUN serum to where you need it, it is important for us to know:

-weight of the dog
-diagnosed disease
-Adress where you want to receive the serum
-Name of the person who will receive the serum
-Mention if the patient has nervous symptoms.

In the following information you will find what you need to buy and will get to know know the scope of ACTINMUN against Distemper and Parvovirus. You will find 3 options:

-For Veterinary Doctors
- For Distemper sick dogs.
- For Parvovirus sick dogs.

In the case of Newcastle disease, we will send you specific information. Each point of the information is important, do not forget that for a quick and better attention you should read the information contained in this manual. Thank you very much

IMMUNE RESPONSE AFTER THE APPLICATION OF THE HIPERINMUNE ACTINMUN SERUM IN PARVOVIRUS AND DISTEMPER

IMMUNE RESPONSE AFTER THE APPLICATION

Dogs become sick of Parvovirus or Distemper because they lost or did not produce antibodies against these viruses before becoming infected, so when injecting ACTINMUN we immediately transfer the antibodies they need.

When ACTINMUN Hyperimmune Serum is administered intramuscularly, subcutaneously or intravenously in sufficient quantity (4-10 ml / kg) to a puppy suffering from Parvovirus or Distemper, we immediately transmit artificial passive immunity (temporary antibody lending).

The main mission of the immunoglobulins (antibodies) of ACTINMUN is to neutralize the Distemper and Parvovirus Virus to facilitate their elimination. These antibodies reduce the infectivity of the virus, and they do this by inhibiting various stages of the viral reproductive cycle such as binding to the cell membrane and penetration into the cell, facilitating phagocytosis (which the leukocytes eat) by opsonizing them, by binding to the virus in different places of the virus.

The Parvovirus produces alterations in the lymphoid tissue and in the bone marrow which causes a leukopenia (drastic reduction of the number of white blood cells), that is to say it blocks the production of leukocytes (white blood cells) in the Bone Marrow, which produces its exhaustion in the blood circulation and with-it immunosuppression. In the intestinal cells the viruses multiply fundamentally in the intestinal crypts of young animals.

It is therefore very important to administer the ACTINMUN Hyperimmune Serum to the puppy as soon as possible while he has enough leukocytes in his bloodstream. In parvovirus the prognosis depends on this. The antibodies are specific against the viruses of Parvovirus and Distemper. In Distemper it is recommended to apply ACTINMUN NDV Serum simultaneously, mainly in the early stages.

In Parvovirus it has been observed that puppies are at higher risk between 6 weeks and 6 months of age and the breeds Rottweiler, Doberman pinscher, Pitbull, Stafforshire terrier, Retrievers, German Shepherd and Alaskan malamute have more genetic predisposition to infection; in general, dark-coat dogs (Sherding 1994; Hoskins, 2000).

NEWCASTLE DISEASE IS ALWAYS OF A LIFETIME PROGNOSIS:

NEWCASTLE DISEASE in birds can be cured using the Actinmun and / or Actinmun NDV Serum alone or simultaneously if it is injected within the first days of the disease and the patient receives adequate symptomatic treatment.

The NEWCASTLE and DISTEMPER viruses belong to the same family and genus (Paramixoviridae / Morbillivirus) and therefore can be eliminated by the same ACTINMUN serum. When the virus reaches the central nervous system, the disease goes to the stage of NERVOUS NEWCASTLE, which is always of SEVERE LIFE PROGNOSIS, that is, it becomes a very serious situation because the virus has achieved its final objective, the central nervous system (CNS). The virus reaches the CNS after crossing several systems and organs, causing injuries and clinical signs that sometimes some veterinarians confuse with infections or mild infestations.

Yes, the virus reaches the Central Nervous System (CNS), and there it is established by infecting the neurons causing demyelination. The ACTINMUN NDV serum can eliminate these viruses at the cellular level in the organism of the BIRD, but once the virus is established in the CNS the possibilities diminish due to the same protection mechanisms of the brain (which now also protect to the virus).

In BIRDS the ACTINMUN NDV can reach and eliminate the CNS virus in 70% of treated cases and in other cases the disease continues its course; (see our videos of patients recovered on YouTube in the name of Rubén López Hidalgo). In this stage the ACTINMUN NDV Serum is applied; for birds of 5 kg (10 pounds) or less, inject 2ml of ACTINMUN NDV, for a bird of 5.01 -10 kilos (10 to 20 pounds) of weight inject 3 ml of ACTINMUN NDV, 4 ml of ACTINMUN NDV for 15 kg ( 30 Pounds) or less; every 12 hours for 3-6 times subcutaneously in the inner part of the thigh and if it is not possible in the leg, subcutaneous is applied in the breast (for greater weights in kg, consult the manual).

The patient must receive appropriate antibiotics for birds and appropriate symptomatic treatment for about 8 days and remain in a quiet place).

MORE ABOUT NERVOUS DISTEMPER.

The initial moments of the Disease

In a case of Distemper, the initial moments of the disease are the best to apply the ACTINMUN and / or ACTINMUN NDV Serum, that is, before the virus reaches the central nervous system.

After the disease starts, the virus reaches the brain between day 9 and day 14, and nerve manifestations appear between day 17 and day 21, so the best times to fight the virus with greater possibilities are the first 8 days after the illness began.

The case presented to us may be delayed and even then, you should try to cure your dog with ACTINMUN NDV (already as rescue therapy).

Please read the article on Nervous Distemper that comes in the manual.

I also send you the technical information.

Knowing ACTINMUN; purchase, use and scope.

In this link you can find what you need to buy and know the scope of ACTINMUN against Distemper and Parvovirus and ACTINMUN NDV against Distemper. You will find 3 options:

-For Veterinary Doctors
-For Distemper sick dogs.
-For Parvovirus sick dogs.

In the case of Newcastle disease, we will send you specific information.
Each point of the information is important, do not forget that for a quick and better attention you should read the information contained in this manual.

ACTINMUN PURCHASE GUIDE
http://www.actinmun.com/guiacompra.html

Please send us this information to quote and send the ACTINMUN Serum to you: The zip code is essential. Write us to actinmun@gmail.com and send us the name of who will receive the ACTINMUN SERUM, full address with zip code, illness, current symptoms, weight of your dog and time it has been ill; With this information we can quote the ACTINMUN or ACTINMUN NDV serum that your dog requires and the shipping cost. With that information, the shipping area will send you the quote. Please watch videos of cases like your dog’s case on YouTube in the name of Rubén López Hidalgo.

EXPORT OF ACTINMUN AND ACTINMUN NDV

It is now possible to export the ACTINMUN Serum for individual use, however the success of your arrival also depends on the Customs of each Country (we have been very successful in sending this way). We have it lyophilized, that is to say dehydrated (it does not require refrigeration for the shipment and lasts more than a year if it is kept in freezing at minus 20 ° c) ready to be reconstituted with injectable water (reconstituted requires refrigeration 4-8 ° c). We will gladly do the complete process of sending the Actinmun Serum through FEDEX.

The Serum will be sent lyophilized in a vacuum plastic bag with a label and a medical prescription and once it is received, it will be placed in a sterile glass bottle of 6.10, 20, 40 ml, etc. (depending on the amount that you have purchased from Actinmun or Actinmun NDV) with a sterile rubber stopper, cap and seal, reconstituting the Serum with injectable water (purchased from a human pharmacy) and you must use the ACTINMUN Serum on your dog following the instructions in the Manual that you should receive from our side from our email actinmun@gmail.com or download from the pages www.actinmun.com and www.hidalgohospitaldemascotas.com.

Once the Serum is reconstituted, it is kept refrigerated and if it is not going to be used it must be frozen. To convert your currency to Mexican pesos and calculate the costs of the ACTINMUN Serums, consider that we paid $ 18.35 Mexican pesos for one US dollar (daily variation). You can also pay for WESTERN UNION on behalf of Rubén López Hidalgo or electronic transfer.
Please send us your full details to the mail actinmun@gmail.com including the postal code to tell the cost of shipping to your country. And if you have any doubt about what you should buy, send your dog's weight, illness and signs. and symptoms that he has presented and that he currently presents.
Please watch videos of cases like your dog’s case on YouTube in the name of Rubén López Hidalgo.

THE NERVOUS DISTEMPER IS ALWAYS OF SEVERE LIFE PROGNOSIS:

The Distemper can be cured using the Actinmun and Actinmun NDV Serum simultaneously while it is within the first days of the disease and the patient receives an adequate symptomatic treatment. When the virus reaches the central nervous system, the disease goes to the stage of NERVOUS DISTEMPER which is always of SEVERE VITAL PROGNOSIS, that is, it becomes a very serious situation because the virus has achieved its final objective, the Central nervous system, this happens after the virus crosses several systems and organs causing injuries and clinical signs that sometimes, some veterinarians, confuse with infections or mild infestations.

Yes, the virus reaches the Central Nervous System (CNS), and there it is established by infecting the neurons causing demyelination, which means the loss of the myelin that surrounds and protects the nerve fibers (manifested as nervous Tics).

Neurons will be occupied by the virus to replicate itself (as if it were cloned using DNA and RNA from the nerve cell) and its presence in the neurons will stimulate the arrival of defense cells called CYTOTOXIC T LYMPHOCYTES whose function is to eliminate infected cells. microorganisms such as viruses or those cells that suffer alterations in their nature and that cease to be compatible with the cells considered HEALTHY (in this way the distemper becomes an autoimmune disease and therefore, the immunostimulants, Interferon and vitamin C are contraindicated in this stage).

Due to the above, a massive destruction is initiated that leads to serious damage of the CNS and that are considered in the literature as irreversible and progressive with serious vital prognosis, that is to say that in the majority of cases it leads to death or to a severe degree of disability (difficulty to incorporate, incoordination, paralysis, howling, etc.) unless the virus is eliminated. The only way to cure these sick dogs is to eliminate these CNS viruses and end up with the stimulus for these killer cells at the same time.

The ACTINMUN NDV serum can eliminate these viruses at the cellular level in the dog's organism, but once the virus is established in the CNS the possibilities decrease dramatically due to the same brain protection mechanisms (which now also protect the virus).

In some dogs ACTINMUN NDV does arrive and eliminates the CNS virus and in other cases the disease runs its course as if nothing had been applied. Finally, although the chances of recovery in Nervous Distemper are few, they are real, and recovery is also possible (see our videos of patients recovered on YouTube in the name of Rubén López Hidalgo).

In this advanced stage of distemper (more than 9 days sick) the ACTINMUN NDV Serum is applied every 12 hours for 6 times subcutaneously in the inner part of the thigh and / or in the Cisterna Magna when we do not see results with the subcutaneous application or well in very advanced cases (see the manual).

RECOMMENDATIONS IN CASE OF DISTEMPER.

If the dog shows nervous signs, hard plantar bearings, and has been sick for more than 9 days, we should use the ACTINMUN NDV serum every 12 hours for 6 times. If the dog has been sick for less time and has other symptoms that are not of nervous origin, we can use Actinmun ndv (specific Antimorbillivirus serum against distemper) and also the Hyperimmune Serum ACTINMUN against parvovirus and distemper (antibodies).

RECOMMENDATIONS ON THE APPLICATION OF THE CISTERNA MAGNA.

The application in the Cisterna Magna can be done by a competent doctor or in the Hospital de Mascotas Hidalgo of Atlixco, Puebla, Mexico (make an appointment at (+52) 2444459888). This is a high-risk procedure and is the last chance to rescue the dog from this terrible disease and some dog could die in the anesthesia or days later due to brain damage that exists caused by the virus and its effects and complications (once made the procedure, the patient must be accompanied by antibiotic application and symptomatic treatment for about 8 days and remain in a dark and quiet place).

ACTINMUN in ENGLISH